First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoyl.
نویسندگان
چکیده
Competitive kinetic experiments utilising free radical carbonylation chemistry provide a first estimate for the rate constant for 6-endo cyclization of the 6-aza-7-ethyl-5-hexenoyl radical of (4.8 +/- 2.4) x 10(6) s(-1) at 90 degrees C in benzene, in good agreement with ONIOM-G3(MP2)-CC+COSMO-RS calculations (6.8 x 10(6) s(-1)).
منابع مشابه
First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoylw
It is now well established that radical carbonylation chemistry is useful for the construction of heterocycles. For example, one of us has shown that, unlike alkyl radicals, acyl radicals formed by the reaction of alkyl radicals with carbon monoxide are N-philic and react to form a variety of lactams (Scheme 1). These observations have been rationalised as being the result of multiorbital inter...
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 35 شماره
صفحات -
تاریخ انتشار 2010